Catalog No.: 53404
Turnaround Time: 3-5 Days
Cross-reactivity: Human, Baboon, Rhesus Macaque; does NOT cross react with Bovine or Porcine
Method: Enzyme-linked Immunosorbant Assay
Application: The IgG quantitation provides the level of IgG present in a given volume of cynomolgus serum or plasma. This assay is currently available for baboons, cynomolgus macaques, and rhesus monkeys. To request validation in another species, please contact us via phone or email, or submit an online inquiry.
Sample Requirements: Please submit a minimum of 0.5mL of frozen sample. For accurate results sample must remain frozen throughout transit. Contact Xeno Diagnostics for further information on alternative sample sizes.
Stability: 110% through 3 freeze/thaw cycles, store at -20°C for up to 1 year
Structure: IgG is a 150 kDa protein which contains two heavy chains and two light chains. The molecule possesses a variable region that is composed of the light chains and one end of each of the heavy chains. The variable region imparts unique binding specificity while the heavy chain (Fcµ) constant region provides functional characteristics of the isotypic class. The IgG class contains four subclasses, IgG1, IgG2, IgG3, and IgG4, each possessing different biological properties and functions.
Production: Plasma cells synthesize IgG after antigenic stimulation. The IgG synthesized will recognize and bind to the specific stimulating antigen.