Xeno Diagnostics has two main donor platforms. The first program utilizes discarded buffy coats from the local blood donation center. These donors are all screened for infectious diseases at the time of blood collection. While large quantities of PBMCs can be banked by this process, the donors are not able to be recalled, so the lots produced are finite.
To address this issue, Xeno implemented a second donor program. Xeno is able to recruit, draw, and cryopreserve PBMC’s, plasma, and serum from local donors. This program has been reviewed by an external institutional review board (IRB), and donors have consented to the use of their donated materials. By maintaining our own donor pool, we can perform assays using either fresh or cryopreserved cells.
Besides humans, Xeno has isolated PBMCs from baboons, cows, cynomolgus macaques, pigs, goats, dogs, cats, and rats. Animal specimens are processed less than 24 hours from blood draw and are cryopreserved in our state-of-the-art storage facilities. Our storage facilities are temperature controlled and monitored 24/7 with emergency power backups and redundant equipment for specimens stored at +4°C, -20°C, -80°C, and liquid nitrogen.
Whole blood specimens can be shipped to Xeno for PBMC isolation and cryopreservation. Frozen cells can be maintained at Xeno or shipped back to your facility using LN2 dry shippers or on dry ice. Please contact us to learn more about our custom cryopreservation services.
In addition to the PBMC isolations, human and cynomolgus macaque cell subsets to include CD3, CD4, CD8, and monocytes can be isolated and phenotypically confirmed by flow cytometry for immediate use or cryopreserved for future use.