Full Length Single Chain, A Novel gp120-CD4 Fusion HIV Subunit Vaccine, Does Not Cause a Deleterious Autoimmune CD4 Response in Cynomolgus Macaques

Full length single chain (FLSC) is a novel HIV vaccine that presents conserved CD4i epitopes on HIV envelope. The constrained structure is achieved with single chain complexes of gp120 and CD4 fragments. FLSC elicits cross-reactive antibodies and heterologous protection against SHIV/SIV in three independent…read more